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Kay E Davies Selected Research

Wasting Syndrome (Wasting Disease)

1/2020Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
1/2019Embryonic myosin is a regeneration marker to monitor utrophin-based therapies for DMD.
12/2018Micro-utrophin Improves Cardiac and Skeletal Muscle Function of Severely Affected D2/mdx Mice.
1/2017Pharmacological advances for treatment in Duchenne muscular dystrophy.
8/2015Second-generation compound for the modulation of utrophin in the therapy of DMD.
5/2011Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse.
10/2002The role of utrophin in the potential therapy of Duchenne muscular dystrophy.
4/2002Function and genetics of dystrophin and dystrophin-related proteins in muscle.

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Kay E Davies Research Topics

Disease

54Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
10/2022 - 04/2002
11Muscular Dystrophies (Muscular Dystrophy)
01/2016 - 02/2002
9Spinal Muscular Atrophy (Progressive Muscular Atrophy)
04/2014 - 11/2004
8Wasting Syndrome (Wasting Disease)
01/2020 - 04/2002
6Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
11/2019 - 06/2009
5Neurodegenerative Diseases (Neurodegenerative Disease)
11/2019 - 10/2004
5Intellectual Disability (Idiocy)
01/2014 - 10/2004
4Inborn Genetic Diseases (Disease, Hereditary)
10/2022 - 01/2007
4Muscle Weakness
10/2020 - 11/2011
4Cardiomyopathies (Cardiomyopathy)
03/2015 - 06/2006
4Muscular Diseases (Myopathy)
12/2007 - 02/2002
3Schizophrenia (Dementia Praecox)
11/2021 - 01/2008
2Neuromuscular Diseases (Neuromuscular Disease)
10/2022 - 10/2020
2Inflammation (Inflammations)
08/2019 - 06/2012
2Nervous System Diseases (Neurological Disorders)
02/2016 - 10/2011
2Hypoxia (Hypoxemia)
01/2016 - 04/2012
2Disease Progression
05/2015 - 06/2009
2Fibrosis (Cirrhosis)
06/2012 - 01/2012
2Hypertrophy
01/2012 - 06/2006
2Cerebellar Ataxia (Dysmetria)
06/2011 - 12/2009
2Necrosis
12/2008 - 10/2003
2Leukemia
01/2007 - 10/2004
2Heart Failure
06/2006 - 01/2005
1Rheumatoid Arthritis
01/2020
1Neuroinflammatory Diseases
11/2019
1Frontotemporal Dementia (Semantic Dementia)
11/2019
1Hyperoxia
01/2019
1Hearing Loss (Hearing Impairment)
02/2016
1Seizures (Absence Seizure)
02/2016
1Mitochondrial Diseases (Mitochondrial Disease)
01/2016
1Sarcoma (Soft Tissue Sarcoma)
06/2015
1Respiratory Insufficiency (Respiratory Failure)
03/2015
1Mucolipidoses (Sialidosis)
09/2014
1Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
09/2014
1Parkinsonian Disorders (Parkinsonism)
02/2014
1Parkinson Disease (Parkinson's Disease)
02/2014
1Kyphosis
04/2012
1Spinal Curvatures (Spinal Curvature)
04/2012
1Motor Neuron Disease (Primary Lateral Sclerosis)
12/2009

Drug/Important Bio-Agent (IBA)

41DystrophinIBA
08/2021 - 04/2002
30Proteins (Proteins, Gene)FDA Link
08/2021 - 04/2002
20UtrophinIBA
01/2022 - 10/2002
4DesminIBA
12/2007 - 02/2002
3ezutromidIBA
12/2020 - 10/2019
3AntioxidantsIBA
01/2016 - 06/2012
3Superoxide Dismutase-1IBA
04/2014 - 06/2009
2OligonucleotidesIBA
10/2022 - 02/2011
2AMPA Receptors (AMPA Receptor)IBA
11/2021 - 01/2018
2AcidsIBA
11/2021 - 01/2018
2OxazolesIBA
12/2020 - 01/2020
2DNA-Binding Proteins (DNA Binding Protein)IBA
11/2019 - 06/2015
2SMT C1100IBA
10/2019 - 06/2015
2chenodeoxycholate sulfate conjugate (CDCS)IBA
01/2016 - 04/2012
2RNA (Ribonucleic Acid)IBA
06/2015 - 04/2012
2Antisense OligonucleotidesIBA
03/2015 - 02/2011
2DNA (Deoxyribonucleic Acid)IBA
03/2015 - 11/2006
2Transcription Factors (Transcription Factor)IBA
01/2014 - 11/2008
2Protein Isoforms (Isoforms)IBA
03/2009 - 08/2004
2TubulinIBA
01/2007 - 06/2006
2Cytoskeletal ProteinsIBA
06/2006 - 01/2005
2cysteine and glycine-rich protein 3IBA
06/2006 - 01/2005
1Glutamic Acid (Glutamate)FDA Link
11/2021
1BenzoxazolesIBA
01/2020
1EstersIBA
01/2020
1Dystrophin-Associated Protein ComplexIBA
08/2019
1Biomarkers (Surrogate Marker)IBA
08/2019
1Myosins (Myosin)IBA
01/2019
1Indicators and Reagents (Reagents)IBA
01/2019
1Protease La (Endopeptidase La)IBA
01/2019
1Proteasome Endopeptidase Complex (Proteasome)IBA
01/2019
1Hypoxia-Inducible Factor-Proline DioxygenasesIBA
01/2016
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2016
1Acetic Acid (Vinegar)FDA LinkGeneric
01/2016
1Telomerase (Telomerase Reverse Transcriptase)IBA
01/2016
1Oxygen (Dioxygen)IBA
01/2016
1imidazole mustard (BIC)IBA
01/2016
1CytokinesIBA
01/2016
1LigandsIBA
01/2016
1Nonsense Codon (Nonsense Mutation)IBA
03/2015
1Pharmaceutical PreparationsIBA
09/2014
1UDP- N- acetylglucosamine- lysosomal- enzyme- N- acetylglucosaminephosphotransferaseIBA
09/2014
1EnzymesIBA
09/2014
1Mannose (D-Mannose)IBA
09/2014
1SynucleinsIBA
02/2014
1Dopamine (Intropin)FDA LinkGeneric
02/2014
1Small Nuclear RNA (snRNA)IBA
06/2012
1Free RadicalsIBA
06/2012
1HSP72 Heat-Shock ProteinsIBA
04/2012
1BGP 15IBA
04/2012
1DobutamineFDA LinkGeneric
01/2012
1GadoliniumIBA
01/2012
1Reactive Oxygen Species (Oxygen Radicals)IBA
10/2011
1CationsIBA
06/2011
1U7 small nuclear RNA (U7 snRNA)IBA
01/2011
1PeripherinsIBA
08/2010
1Insulin-Like PeptidesIBA
12/2009
1Insulin-Like Growth Factor I (IGF-1)IBA
12/2009

Therapy/Procedure

15Therapeutics
01/2020 - 10/2002
1Muscle Denervation
11/2019
1Palliative Care (Palliative Therapy)
01/2013